COLOR III Trial:

A randomized clinical trial comparing transanal and traditional
laparoscopic TME for rectal cancer.

color3-300x274

To improve oncological and functional outcomes of patients with rectal cancer new techniques are being developed. Traditional abdominal laparoscopic resection of low rectal cancer remains challenging with a relative high risk of irradicality.

The introduction of transanal single port surgery has led to the transanal total mesorectal excision (TaTME) technique. The rectum including the total mesorectum is mobilized transanally in a reversed way with minimally invasive surgery. The TaTME technique for low and mid rectal cancer has potential benefits: better specimen quality with better radicality, less morbidity as result of avoiding extraction wounds in the majority of patients and more sphincter saving rectal resections without compromising oncological outcomes.

Currently, cohort series have demonstrated potential benefits of the TaTME for rectal cancer including a low morbidity rate and a high rate of sphincter saving procedures. The COLOR and COLOR II study group have conducted multicenter and international
trials including over 2000 patients and demonstrated the benefit of laparoscopic colonic and rectal cancer surgery.

Our goal is to evaluate the TaTME technique compared to conventional laparoscopic rectal resection for patients with mid and low rectal cancer in an international randomized trial: the COLOR III trial. We aim to conduct a high quality trial, with high standards of imaging, surgery, pathology and follow-up with frequent auditing.

2208, 2019

Accrual reaches 200!

Inclusion #200 ! The 200th inclusion was registered August 20th [...]

1807, 2019

Update of COLORIII slides available!

For all collaborators and/or interested colleagues we have updated the [...]

1007, 2019

FAH Chongqing opens as 8th site from larger China

We congratulate Professsor Hongyu Zhang, local PI in the First [...]

1007, 2019

E. Agnelli, Italy open

Ospedale Agnelli in Pinerolo Italy isopen for inclusion. We congratulate [...]

A Multicentre Randomized Clinical Trial comparing transanel TME Versus Traditional Laparoscopic TME for MID and LOW rectal cancer

To assure technical and oncological quality of the TaTME technique, all participating centers will be conducted a surgical quality assessment.

 

Data entry, including report of a SAE,  can be done directly into the eCRF’s on the online platform. On the download section you can find pdf’s of most forms and other useful documents.